Study on the extraction process of sesquiterpenoid fractions and bioactives from Homalomena gigantea

Pham Viet Ty , Ngo Thi Phuong Hang and Pham Thanh *

* Corresponding author: (phamthanh@hueuni.edu.vn)

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Received: Apr 19, 2023
Revised: Jun 18, 2023
Accepted: Jun 29, 2023
Published: Apr 20, 2026
Title: Study on the extraction process of sesquiterpenoid fractions and bioactives from Homalomena gigantea
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Tý, P. V., Hằng, N. T. P., & Thành, P. . (2026). Study on the extraction process of sesquiterpenoid fractions and bioactives from Homalomena gigantea. Journal of Science and Education, 66(02). Retrieved from https://tckhgd.dhsphue.edu.vn/index.php/jse/article/view/528
Issue
Vol. 66 No. 02 (2026): Journal of Science and Education: Natural Science - Technology
Section
Journal of Science and Education: Natural Science - Technology

Abstract

Homalomena gigantea is a native plant naturally distributed in Vietnam. In traditional Vietnamese, it is used to alleviate back pain and fatigue in the arms and legs. Recent studies have shown that the giant heartleaf plant has excellent anti-osteoporotic activity. In this our datas, we utilized n-hexane, dichloromethane, and ethyl acetate solvents to create fractionated in order to develop a process for extracting sesquiterpenoid fractions containing purified sesquiterpene compounds. The results successfully established a process for extracting fractions containing sesquiterpenes and purified compounds, namely Oplopanone, 1β,4β,6α-trihydroxy-eudesmane, 1β,4β,7α-trihydroxy-eudesmane, and Bullatrantriol.
Keywords: Homalomena gigantea, Sesquiterpene, Thien nien kien la lon

Tóm tắt

Cây thiên niên kiện lá lớn (Homalomena gigantea) là cây bản địa và phân bố tự nhiên tại Việt Nam. Trong y học cổ truyền Việt Nam sử dụng để chống đau lưng, mỏi chân tay. Một vài công trình công bố mới đây cho thấy cây thiên niên kiện lá lớn có hoạt tính chống loãng xương rất tốt. Trong đề tài này chúng tôi đã sử dụng các dung môi n-hexan, dichloromethane, ethyl acetate để tạo thành cao chiết phân đoạn và hoạt chất tinh sạch để xây dựng quy trình tách phân đoạn có chứa sesquiterpene và các hoạt chất sesquiterpene tinh sạch. Kết quả đã xây dựng được quy trình tách chiết các phân đoạn có chứa sesquiterpene và các chất tinh sạch Oplopanone; 1β,4β,6α-trihydroxy-eudesmane; 1β,4β,7α-trihydroxy-eudesmane; Bullatrantriol.
Từ khóa: Homalomena gigantea, Sesquiterpene, Thiên niên kiện lá lớn

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